The Staycation Express will be linking Carlisle, Appleby ,Settle and Skipton on the 72 mile journey.
Passengers will enjoy the breathtaking sites that the Dales and Fells have to offer, in stunning autumnal light.
Full meals or snacks are served, freshly cooked, by the onboard chef.
The bar guarantees the best view of England's 'most beautiful line.'
The HST's operate in the special Staycation Express livery and are powered by 43058 and 43059, which were in service with East Midlands Trains (East Midlands Railway) before being withdrawn.