The first new London North Eastern Railway (LNER) trains to run between Middlesbrough and London will start this morning on 13th December.
The daily weekday service in each direction will also connect nearby Thornaby with London King's Cross.
The services will depart Middlesbrough at 07:08 and Thornaby at 07:15, arriving at King's Cross at 10:22.
Northbound from London will leave at 15:25, stopping at York, to Thornaby at 18:08 and Middlesbrough at 18:18.
When the route was first announced, LNER Managing Director David Thorne said:
"The new, direct services from December will see journey times of around three hours between London and Middlesbrough, offering more opportunities for business travel, tourists and international visitors wanting to travel to the Tees Valley."
LNER said more direct services were planned after further work was completed at Middlesbrough station.
"The new, direct services will see journey times of around three hours between London and Middlesbrough, offering more opportunities for business travel, tourists and international visitors wanting to travel to the Tees Valley," he said.
Conservative Tees Valley Mayor Ben Houchen said it would "show businesses all the benefits of being based right here, and help our local companies forge new partnerships".
Middlesbrough Labour MP Andy McDonald said it had to be "just the start" but "being connected to our capital city will be a huge positive for jobs and for our local economy".
The Azuma trains being used on the line will run using overhead electric wires between London and Northallerton then operate under diesel power to and from Middlesbrough.
